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Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
Author(s) -
Wu Xiaojin,
Lei Chuanhu,
Yue Guizhou,
Zhou Jianrong Steve
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504735
Subject(s) - palladium , catalysis , chemistry , organic chemistry
Many 1,3‐azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three‐membered rings is retained in the products. Thus, the cyclopropyl–halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl radicals are not involved in the productive pathway.