Metal‐Free Radical [2+2+1] Carbocyclization of Benzene‐Linked 1, n ‐Enynes: Dual C(sp 3 )H Functionalization Adjacent to a Heteroatom | Zendy

Hu Ming | Zendy; Fan JianHong | Zendy; Liu Yu | Zendy; Ouyang XuanHui | Zendy; Song RenJie | Zendy; Li JinHeng | Zendy

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Metal‐Free Radical [2+2+1] Carbocyclization of Benzene‐Linked 1, n ‐Enynes: Dual C(sp 3 )H Functionalization Adjacent to a Heteroatom

Author(s) -

Hu Ming,

Fan JianHong,

Liu Yu,

Ouyang XuanHui,

Song RenJie,

Li JinHeng

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201504603

Subject(s) - heteroatom , annulation , benzene , chemistry , surface modification , medicinal chemistry , metal , stereochemistry , photochemistry , organic chemistry , catalysis , ring (chemistry)

A new metal‐free oxidative radical [2+2+1] carbocyclization of benzene‐linked 1, n ‐enynes with two C(sp 3 )H bonds adjacent to the same heteroatom is described. This method achieves two C(sp 3 )H oxidative functionalizations and an annulation, thus providing efficient and general access to a variety of fused five‐membered carbocyclic hydrocarbons.

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