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N 6 ‐Methyladenine: A Potential Epigenetic Mark in Eukaryotic Genomes
Author(s) -
Summerer Daniel
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504594
Subject(s) - epigenetics , genome , biology , genetics , gene , bacterial genome size , dna methylation , dna , regulation of gene expression , gene expression , computational biology , evolutionary biology
N 6 ‐methyladenine (6mA) is known to be an epigenetic mark in bacterial genomes. Three studies have now demonstrated the existence of significant levels of 6mA in the genomes of several phylogenetically distinct eukaryotes, along with findings that suggest that 6mA may act as a dynamic epigenetic mark in the regulation of eukaryotic gene expression.