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Enantiospecific CH Activation Using Ruthenium Nanocatalysts
Author(s) -
Taglang Céline,
MartínezPrieto Luis Miguel,
del Rosal Iker,
Maron Laurent,
Poteau Romuald,
Philippot Karine,
Chaudret Bruno,
Perato Serge,
Sam Lone Anaïs,
Puente Céline,
Dugave Christophe,
Rousseau Bernard,
Pieters Grégory
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504554
Subject(s) - stereocenter , ruthenium , nanomaterial based catalyst , chemistry , heteroatom , selectivity , stereochemistry , combinatorial chemistry , catalysis , enantioselective synthesis , organic chemistry , ring (chemistry)
The activation of CH bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific CH activation has been developed to date. We herein report an enantiospecific CH activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α‐position of the directing heteroatom results from a four‐membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.