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X‐ray Radiation‐Controlled NO‐Release for On‐Demand Depth‐Independent Hypoxic Radiosensitization
Author(s) -
Fan Wenpei,
Bu Wenbo,
Zhang Zhen,
Shen Bo,
Zhang Hui,
He Qianjun,
Ni Dalong,
Cui Zhaowen,
Zhao Kuaile,
Bu Jiwen,
Du Jiulin,
Liu Jianan,
Shi Jianlin
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504536
Subject(s) - x ray , materials science , controlled release , nanotechnology , in vivo , radiation , photon upconversion , on demand , peg ratio , optoelectronics , luminescence , computer science , optics , physics , multimedia , microbiology and biotechnology , finance , economics , biology
Abstract Multifunctional stimuli‐responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on‐demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X‐ray‐controlled NO‐releasing upconversion nanotheranostic system (termed as PEG‐USMSs‐SNO) by engineering UCNPs with S‐nitrosothiol (R‐SNO)‐grafted mesoporous silica. The PEG‐USMSs‐SNO is designed to respond sensitively to X‐ray radiation for breaking down the SN bond of SNO to release NO, which leads to X‐ray dose‐controlled NO release for on‐demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live‐body permeability of X‐ray, our developed PEG‐USMSs‐SNO may provide a new technique for achieving depth‐independent controlled NO release and positioned radiotherapy enhancement against deep‐seated solid tumors.