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A Single Stereodynamic Center Modulates the Rate of Self‐Assembly in a Biomolecular System
Author(s) -
Zhang Yitao,
Malamakal Roy M.,
Chenoweth David M.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504459
Subject(s) - chirality (physics) , stereocenter , folding (dsp implementation) , chemistry , self assembly , context (archaeology) , nanotechnology , homochirality , design elements and principles , stereochemistry , chemical physics , enantioselective synthesis , catalysis , physics , materials science , computer science , biochemistry , organic chemistry , enantiomer , software engineering , chiral symmetry breaking , engineering , biology , quark , paleontology , quantum mechanics , nambu–jona lasinio model , electrical engineering
Abstract Chirality is a property of asymmetry important to both physical and abstract systems. Understanding how molecular systems respond to perturbations in their chiral building blocks can provide insight into diverse areas such as biomolecular self‐assembly, protein folding, drug design, materials, and catalysis. Despite the fundamental importance of stereochemical preorganization in nature and designed materials, the ramifications of replacing chiral centers with stereodynamic atomic mimics in the context of biomolecular systems is unknown. Herein, we demonstrate that replacement of a single amino acid stereocenter with a stereodynamic nitrogen atom has profound consequences on the self‐assembly of a biomolecular system. Our results provide insight into how the fundamental biopolymers of life would behave if their chiral centers were not configurationally stable, highlighting the vital importance of stereochemistry as a pre‐organizing element in biomolecular folding and assembly events.