Metal‐Free Decarboxylative Cyclization/Ring Expansion: Construction of Five‐, Six‐, and Seven‐Membered Heterocycles from 2‐Alkynyl Benzaldehydes and Cyclic Amino Acids | Zendy

Samala Srinivas | Zendy; Singh Gajendra | Zendy; Kumar Ravi | Zendy; Ampapathi Ravi Sankar | Zendy; Kundu Bijoy | Zendy

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Metal‐Free Decarboxylative Cyclization/Ring Expansion: Construction of Five‐, Six‐, and Seven‐Membered Heterocycles from 2‐Alkynyl Benzaldehydes and Cyclic Amino Acids

Author(s) -

Samala Srinivas,

Singh Gajendra,

Kumar Ravi,

Ampapathi Ravi Sankar,

Kundu Bijoy

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201504429

Subject(s) - decarboxylation , chemistry , ring (chemistry) , metal , medicinal chemistry , stereochemistry , organic chemistry , catalysis

A one pot synthesis of 1 H ‐benzo[g]indoles, tetrahydrobenzo[h]quinolines, and naphtho[1,2‐b]azepines from 2‐alkynyl benzaldehydes and cyclic amino acids is reported. The salient feature of the strategy involves formation of three new bonds (one CN and two CC bonds) by a metal‐free decarboxylation/cyclization/one‐carbon ring expansion sequence in one pot.

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