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Towards the Production of Universal Blood by Structure‐Guided Directed Evolution of Glycoside Hydrolases
Author(s) -
Sun Zhoutong,
Ilie Adriana,
Reetz Manfred T.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504318
Subject(s) - glycan , glycoside hydrolase , glycoside , cleavage (geology) , chemistry , biochemistry , stereochemistry , hydrolysis , biology , glycoprotein , paleontology , fracture (geology)
Coming closer to a vision : Directed evolution has been applied to a glycoside hydrolase for increased activity in the selective cleavage of A‐ and B‐antigens from linkages on red blood cell surface glycans. The results are a major step forward in the challenging endeavor of producing universal blood.