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A Hollow Foldecture with Truncated Trigonal Bipyramid Shape from the Self‐Assembly of an 11‐Helical Foldamer
Author(s) -
Eom JaeHoon,
Gong Jintaek,
Kwon Sunbum,
Jeon Aram,
Jeong Rokam,
Driver Russell W.,
Lee HeeSeung
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504248
Subject(s) - foldamer , microscale chemistry , supramolecular chemistry , crystallography , self assembly , nanotechnology , structural motif , chemistry , trigonal bipyramidal molecular geometry , materials science , stereochemistry , crystal structure , biochemistry , mathematics education , mathematics
The creation of self‐assembling microscale architectures that possess new and useful physical properties remains a significant challenge. Herein we report that an 11‐helical foldamer self‐assembles in a controlled manner to form a series of 3D foldectures with unusual three‐fold symmetrical shapes that are distinct from those generated from 12‐helical foldamers. The foldamer packing motif was revealed by powder X‐ray diffraction technique, and provides an important link between the molecular‐level symmetry and the microscale morphologies. The utility of foldectures with hollow interiors as robust and well‐defined supramolecular hosts was demonstrated for inorganic, organic, and even protein guests. This work will pave the way for the design of functional foldectures with greater 3D shape diversity and for the development of biocompatible delivery vehicles and containment vessels.