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Back Cover: CH Activation Generates Period‐Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock (Angew. Chem. Int. Ed. 24/2015)
Author(s) -
Oshima Tsuyoshi,
Yamanaka Iori,
Kumar Anupriya,
Yamaguchi Junichiro,
NishiwakiOhkawa Taeko,
Muto Kei,
Kawamura Rika,
Hirota Tsuyoshi,
Yagita Kazuhiro,
Irle Stephan,
Kay Steve A.,
Yoshimura Takashi,
Itami Kenichiro
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504172
Subject(s) - cryptochrome , period (music) , circadian rhythm , circadian clock , molecule , chemistry , period length , biophysics , stereochemistry , biology , physics , neuroscience , organic chemistry , acoustics , mathematics , discrete mathematics
A focused library of KL001 derivatives, a period‐lengthening modulator of the mammalian circadian clock, was rapidly constructed by CH activation chemistry. In their Communication on page 7193 ff., S. Irle, T. Yoshimura, K. Itami et al. describe both new period‐lengthening molecules and the first period‐shortening molecules that target the cryptochrome. The picture (Haruko Hirukawa) illustrates the power of the CH activation catalyst in triggering opposite modes of action in small molecules.