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Plasmonic Colloidosomes as Three‐Dimensional SERS Platforms with Enhanced Surface Area for Multiphase Sub‐Microliter Toxin Sensing
Author(s) -
PhanQuang Gia Chuong,
Lee Hiang Kwee,
Phang In Yee,
Ling Xing Yi
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504027
Subject(s) - nanotechnology , materials science , plasmon , multiplex , merge (version control) , optoelectronics , computer science , bioinformatics , information retrieval , biology
Colloidosomes are robust microcapsules attractive for molecular sensing because of their characteristic micron size, large specific surface area, and dual‐phase stability. However, current colloidosome sensors are limited to qualitative fluorogenic receptor‐based detection, which restrict their applicability to a narrow range of molecules. Here, we introduce plasmonic colloidosome constructed from Ag nanocubes as an emulsion‐based 3D SERS platform. The colloidosomes exhibit excellent mechanical robustness, flexible size tunability, versatility to merge, and ultrasensitivity in SERS quantitation of food/industrial toxins down to sub‐femtomole levels. Using just 0.5 μL of sample volumes, our plasmonic colloidosomes exhibit >3000‐fold higher SERS sensitivity over conventional suspension platform. Notably, we demonstrate the first high‐throughput multiplex molecular sensing across multiple liquid phases.