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Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis
Author(s) -
Zhu Zhi,
Guan Zhichao,
Liu Dan,
Jia Shasha,
Li Jiuxing,
Lei Zhichao,
Lin Shuichao,
Ji Tianhai,
Tian Zhongqun,
Yang Chaoyong James
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201503963
Subject(s) - bioanalysis , signal (programming language) , sensitivity (control systems) , nanotechnology , computer science , component (thermodynamics) , variety (cybernetics) , biochemical engineering , chemistry , materials science , artificial intelligence , electronic engineering , physics , engineering , thermodynamics , programming language
Herein, we demonstrate that a very familiar, yet underutilized, physical parameter—gas pressure—can serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas‐generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low‐cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings.