Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis | Zendy

Zhu Zhi | Zendy; Guan Zhichao | Zendy; Liu Dan | Zendy; Jia Shasha | Zendy; Li Jiuxing | Zendy; Lei Zhichao | Zendy; Lin Shuichao | Zendy; Ji Tianhai | Zendy; Tian Zhongqun | Zendy; Yang Chaoyong James | Zendy

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Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis

Author(s) -

Zhu Zhi,

Guan Zhichao,

Liu Dan,

Jia Shasha,

Li Jiuxing,

Lei Zhichao,

Lin Shuichao,

Ji Tianhai,

Tian Zhongqun,

Yang Chaoyong James

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201503963

Subject(s) - bioanalysis , signal (programming language) , sensitivity (control systems) , nanotechnology , computer science , component (thermodynamics) , variety (cybernetics) , biochemical engineering , chemistry , materials science , artificial intelligence , electronic engineering , physics , engineering , thermodynamics , programming language

Herein, we demonstrate that a very familiar, yet underutilized, physical parameter—gas pressure—can serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas‐generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low‐cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings.

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