Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B | Zendy

Murray Alexander T. | Zendy; Dowley Myles J. H. | Zendy; PradauxCaggiano Fabienne | Zendy; Baldansuren Amgalanbaatar | Zendy; Fielding Alistair J. | Zendy; Tuna Floriana | Zendy; Hendon Christopher H. | Zendy; Walsh Aron | Zendy; LloydJones Guy C. | Zendy; John Matthew P. | Zendy; Carbery David R. | Zendy

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Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B

Author(s) -

Murray Alexander T.,

Dowley Myles J. H.,

PradauxCaggiano Fabienne,

Baldansuren Amgalanbaatar,

Fielding Alistair J.,

Tuna Floriana,

Hendon Christopher H.,

Walsh Aron,

LloydJones Guy C.,

John Matthew P.,

Carbery David R.

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201503654

Subject(s) - chemistry , monoamine oxidase , catalysis , mimicry , biogenic amine , amine gas treating , monoamine oxidase b , biochemistry , organic chemistry , enzyme , biology , neurotransmitter , ecology , receptor

The flavoenzyme monoamine oxidase (MAO) regulates mammalian behavioral patterns by modulating neurotransmitters such as adrenaline and serotonin. The mechanistic basis which underpins this enzyme is far from agreed upon. Reported herein is that the combination of a synthetic flavin and alloxan generates a catalyst system which facilitates biomimetic amine oxidation. Mechanistic and electron paramagnetic (EPR) spectroscopic data supports the conclusion that the reaction proceeds through a radical manifold. This data provides the first example of a biorelevant synthetic model for monoamine oxidase B activity.

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