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Direct Ruthenium‐Catalyzed Hydrogenation of Carboxylic Acids to Alcohols
Author(s) -
Cui Xinjiang,
Li Yuehui,
Topf Christoph,
Junge Kathrin,
Beller Matthias
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201503562
Subject(s) - triphos , ruthenium , catalysis , chemistry , organic chemistry , carboxylic acid , lewis acids and bases , substrate (aquarium) , combinatorial chemistry , biology , ecology
The “green” reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac) 3 , triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass‐derived compounds can be smoothly reduced.