Direct Ruthenium‐Catalyzed Hydrogenation of Carboxylic Acids to Alcohols | Zendy

Cui Xinjiang | Zendy; Li Yuehui | Zendy; Topf Christoph | Zendy; Junge Kathrin | Zendy; Beller Matthias | Zendy

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Direct Ruthenium‐Catalyzed Hydrogenation of Carboxylic Acids to Alcohols

Author(s) -

Cui Xinjiang,

Li Yuehui,

Topf Christoph,

Junge Kathrin,

Beller Matthias

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201503562

Subject(s) - triphos , ruthenium , catalysis , chemistry , organic chemistry , carboxylic acid , lewis acids and bases , substrate (aquarium) , combinatorial chemistry , biology , ecology

The “green” reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac) 3 , triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass‐derived compounds can be smoothly reduced.

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