Premium
Diphenyliodonium‐Catalyzed Fluorination of Arynes: Synthesis of ortho ‐Fluoroiodoarenes
Author(s) -
Zeng Yuwen,
Li Guangyu,
Hu Jinbo
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201503308
Subject(s) - halogenation , aryne , vicinal , fluorine , nucleophile , catalysis , electrophile , chemistry , substrate (aquarium) , salt (chemistry) , electrophilic fluorination , combinatorial chemistry , organic chemistry , oceanography , geology
Described is a one‐pot vicinal fluorination‐iodination of arynes at room temperature. The diphenyliodonium salt proved to be a privileged catalyst for this nucleophilic fluorination process using CsF as a fluorine source, and a subsequent facile electrophilic iodination with C 4 F 9 I was also found to be crucial to ensure the efficient fluorination. This new synthetic protocol has a broad substrate scope under mild reaction conditions.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom