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Hydroaminomethylation Beyond Carbonylation: Allene–Imine Reductive Coupling by Ruthenium‐Catalyzed Transfer Hydrogenation
Author(s) -
Oda Susumu,
Sam Bran,
Krische Michael J.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201503250
Subject(s) - hydroformylation , allene , reductive amination , ruthenium , transfer hydrogenation , regioselectivity , chemistry , imine , catalysis , carbonylation , coupling (piping) , organic chemistry , photochemistry , medicinal chemistry , combinatorial chemistry , rhodium , carbon monoxide , materials science , metallurgy
Ruthenium(II)‐catalyzed hydrogen transfer from 2‐propanol mediates reductive coupling of 1,1‐disubstituted allenes with formaldimines with complete branch‐regioselectivity, thus representing a new method for hydroaminomethylation beyond classical hydroformylation/reductive amination.