Hydroaminomethylation Beyond Carbonylation: Allene–Imine Reductive Coupling by Ruthenium‐Catalyzed Transfer Hydrogenation | Zendy

Oda Susumu | Zendy; Sam Bran | Zendy; Krische Michael J. | Zendy

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Hydroaminomethylation Beyond Carbonylation: Allene–Imine Reductive Coupling by Ruthenium‐Catalyzed Transfer Hydrogenation

Author(s) -

Oda Susumu,

Sam Bran,

Krische Michael J.

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201503250

Subject(s) - hydroformylation , allene , reductive amination , ruthenium , transfer hydrogenation , regioselectivity , chemistry , imine , catalysis , carbonylation , coupling (piping) , organic chemistry , photochemistry , medicinal chemistry , combinatorial chemistry , rhodium , carbon monoxide , materials science , metallurgy

Ruthenium(II)‐catalyzed hydrogen transfer from 2‐propanol mediates reductive coupling of 1,1‐disubstituted allenes with formaldimines with complete branch‐regioselectivity, thus representing a new method for hydroaminomethylation beyond classical hydroformylation/reductive amination.

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