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Well‐Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes
Author(s) -
Prades Amparo,
Fernández Maitane,
Pike Sebastian D.,
Willis Michael C.,
Weller Andrew S.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201503208
Subject(s) - hydroacylation , alkene , rhodium , catalysis , ligand (biochemistry) , terminal (telecommunication) , chemistry , organic chemistry , computer science , receptor , biochemistry , telecommunications
A Rh‐catalyst system based on the asymmetric ligand t Bu 2 PCH 2 P( o ‐C 6 H 4 OMe) 2 is reported that allows for the hydroacylation of challenging internal alkenes with β‐substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe‐group.