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Facile Protocol for Catalytic Frustrated Lewis Pair Hydrogenation and Reductive Deoxygenation of Ketones and Aldehydes
Author(s) -
Mahdi Tayseer,
Stephan Douglas W.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201503087
Subject(s) - deoxygenation , catalysis , chemistry , frustrated lewis pair , toluene , aryl , molecular sieve , organic chemistry , metal , lewis acids and bases , combinatorial chemistry , medicinal chemistry , alkyl
A series of ketones and aldehydes are reduced in toluene under H 2 in the presence of 5 mol % B(C 6 F 5 ) 3 and either cyclodextrin or molecular sieves affording a facile metal‐free protocol for reduction to alcohols. Similar treatment of aryl ketones resulted in metal‐free deoxygenation yielding aromatic hydrocarbons.