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Copper‐Catalyzed Intermolecular Asymmetric Propargylic Dearomatization of Indoles
Author(s) -
Shao Wen,
Li He,
Liu Chuan,
Liu ChenJiang,
You ShuLi
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201503042
Subject(s) - intermolecular force , catalysis , copper , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , molecule
The first copper‐catalyzed intermolecular dearomatization of indoles by an asymmetric propargylic substitution reaction was developed. This method provides a highly efficient synthesis of versatile furoindoline and pyrroloindoline derivatives containing a quaternary carbon stereogenic center and a terminal alkyne moiety with up to 86 % yield and 98 % ee .
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