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Ag 2 and Ag 3 Clusters: Synthesis, Characterization, and Interaction with DNA
Author(s) -
Buceta David,
Busto Natalia,
Barone Giampaolo,
Leal José M.,
Domínguez Fernando,
Giovanetti Lisandro J.,
Requejo Félix G.,
García Begoña,
LópezQuintela M. Arturo
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201502917
Subject(s) - proflavine , intercalation (chemistry) , ethidium bromide , kinetic energy , dna , chemistry , characterization (materials science) , electrochemistry , bromide , crystallography , materials science , nanotechnology , inorganic chemistry , physics , electrode , biochemistry , quantum mechanics
Abstract Subnanometric samples, containing exclusively Ag 2 and Ag 3 clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we show herein that Ag 3 clusters interact with DNA through intercalation, inducing significant structural distortion to the DNA. The lifetime of Ag 3 clusters in the intercalated position is two to three orders of magnitude longer than for classical organic intercalators, such as ethidium bromide or proflavine.