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Cover Picture: Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem (Angew. Chem. Int. Ed. 19/2015)
Author(s) -
Liu Chengwei,
Tagami Koichi,
Minami Atsushi,
Matsumoto Tomoyuki,
Frisvad Jens Christian,
Suzuki Hideyuki,
Ishikawa Jun,
Gomi Katsuya,
Oikawa Hideaki
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201502797
Subject(s) - indole test , diterpene , stereochemistry , chemistry , octane , bicyclic molecule , organic chemistry
The biosynthetic gene cluster of the highly complex indole diterpene penitrem is identified by H. Oikawa et al. in their Communication on page 5748 ff. Thirteen out of the seventeen involved transformations were elucidated by heterologous reconstitution of the relevant genes in Aspergillus oryzae and found to involve a prenylation‐initiated cationic cyclization and two successive P450‐catalyzed oxidative transformations for the installation of the characteristic bicyclo[4.2.0]octane skeleton.