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Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas
Author(s) -
Yang Guang,
O'Duill Miriam,
Gouverneur Véronique,
Krafft Marie Pierre
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201502677
Subject(s) - dipalmitoylphosphatidylcholine , monolayer , fluorocarbon , phospholipid , chemistry , pulmonary surfactant , chemical engineering , molecule , aqueous solution , langmuir , organic chemistry , membrane , biochemistry , engineering , phosphatidylcholine
Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self‐supported on an aqueous solution of C 2 F 5 ‐labeled compounds causes the recruitment and immobilization of the latter in the interfacial film. When the phospholipid forms a liquid‐condensed Gibbs monolayer, which is the case for dipalmitoylphosphatidylcholine (DPPC), the C 2 F 5 ‐labeled molecule remains trapped in the monolayer after removal of F ‐hexane. Investigations involve bubble profile analysis tensiometry (Gibbs films), Langmuir monolayers and microbubble experiments. The new phenomenon was utilized to incorporate a hypoxia biomarker, a C 2 F 5 ‐labeled nitrosoimidazole (EF5), in microbubble shells. This finding opens perspectives in the delivery of fluorinated therapeutic molecules and biomarkers.