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Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage
Author(s) -
Bhowmick Debasish,
Srivastava Shubhi,
D'Silva Patrick,
Mugesh Govindasamy
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201502430
Subject(s) - ebselen , cytoprotection , antioxidant , reactive oxygen species , peroxiredoxin , glutathione peroxidase , glutathione , cytotoxicity , chemistry , oxidative damage , peroxidase , oxidative stress , biochemistry , pharmacology , enzyme , medicine , catalase , in vitro
Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species.