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Cover Picture: Intracellular Modulation of Excited‐State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells (Angew. Chem. Int. Ed. 18/2015)
Author(s) -
Kolemen Safacan,
Işık Murat,
Kim Gyoung Mi,
Kim Dabin,
Geng Hao,
Buyuktemiz Muhammed,
Karatas Tugce,
Zhang XianFu,
Dede Yavuz,
Yoon Juyoung,
Akkaya Engin U.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201502270
Subject(s) - photosensitizer , glutathione , chemistry , photodynamic therapy , cancer cell , excited state , chromophore , intracellular , stereochemistry , combinatorial chemistry , photochemistry , cancer , biochemistry , organic chemistry , enzyme , physics , biology , nuclear physics , genetics
Orthogonal BODIPY dimers offer exciting potential as activatable photosensitizers for photodynamic therapy. In their Communication on page 5340 ff., J. Yoon, E. U. Akkaya et al. report a photosensitizer that is switched on by a reaction with glutathione (GSH). Comparative cell culture data show that the agent is preferentially activated in cancer cells as they feature a higher glutathione level than normal cells.