Cover Picture: Intracellular Modulation of Excited‐State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells (Angew. Chem. Int. Ed. 18/2015) | Zendy

Kolemen Safacan | Zendy; Işık Murat | Zendy; Kim Gyoung Mi | Zendy; Kim Dabin | Zendy; Geng Hao | Zendy; Buyuktemiz Muhammed | Zendy; Karatas Tugce | Zendy; Zhang XianFu | Zendy; Dede Yavuz | Zendy; Yoon Juyoung | Zendy; Akkaya Engin U. | Zendy

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Cover Picture: Intracellular Modulation of Excited‐State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells (Angew. Chem. Int. Ed. 18/2015)

Author(s) -

Kolemen Safacan,

Işık Murat,

Kim Gyoung Mi,

Kim Dabin,

Geng Hao,

Buyuktemiz Muhammed,

Karatas Tugce,

Zhang XianFu,

Dede Yavuz,

Yoon Juyoung,

Akkaya Engin U.

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201502270

Subject(s) - photosensitizer , glutathione , chemistry , photodynamic therapy , cancer cell , excited state , chromophore , intracellular , stereochemistry , combinatorial chemistry , photochemistry , cancer , biochemistry , organic chemistry , enzyme , physics , biology , nuclear physics , genetics

Orthogonal BODIPY dimers offer exciting potential as activatable photosensitizers for photodynamic therapy. In their Communication on page 5340 ff., J. Yoon, E. U. Akkaya et al. report a photosensitizer that is switched on by a reaction with glutathione (GSH). Comparative cell culture data show that the agent is preferentially activated in cancer cells as they feature a higher glutathione level than normal cells.

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