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Gold‐Catalyzed Cascade Cyclization of 2‐Alkynyl‐ N ‐Propargylanilines by Rearrangement of a Propargyl Group
Author(s) -
Tokimizu Yusuke,
Oishi Shinya,
Fujii Nobutaka,
Ohno Hiroaki
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201502256
Subject(s) - propargyl , substituent , aniline , chemistry , indole test , catalysis , medicinal chemistry , nitrogen atom , cascade reaction , stereochemistry , combinatorial chemistry , group (periodic table) , organic chemistry
Gold catalysis enables direct construction of tetracyclic fused indolines through the migration of a propargyl substituent from an aniline nitrogen atom to the C3‐position of an indole from 2‐alkynyl‐ N ‐propargylanilines. This reaction provides rapid access to fused three‐dimensional indolines in a single operation with the formation of four bonds and three rings.