Premium
SpONGE: Spontaneous Organization of Numerous‐Layer Generation by Electrospray
Author(s) -
Jin Gyuhyung,
Shin Mikyung,
Kim SeungHyun,
Lee Haeshin,
Jang JaeHyung
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201502177
Subject(s) - sponge , nanotechnology , scope (computer science) , layer (electronics) , electrospray , drug delivery , materials science , computer science , chemistry , biology , mass spectrometry , chromatography , programming language , botany
Advanced technologies that can mimic hierarchical architectures found in nature can provide pivotal clues for elucidating numerous biological mechanisms. Herein, a novel technology, spontaneous organization of numerous‐layer generation by electrospray (SpONGE), was developed to create self‐assembled and multilayered fibrous structures. The simple inclusion of salts in a polymer solution prior to electrospraying was key to mediating the structural versatilities of the fibrous structures. The SpONGE matrix demonstrated great potential as a crucial building block capable of inducing sequential, localized drug delivery or orchestrating cellular distribution in vivo, thereby expanding its scope of use to cover a variety of biomedical applications.