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Next‐Generation o ‐Nitrobenzyl Photolabile Groups for Light‐Directed Chemistry and Microarray Synthesis
Author(s) -
Kretschy Nicole,
Holik AnnKatrin,
Somoza Veronika,
Stengele KlausPeter,
Somoza Mark M.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201502125
Subject(s) - chemistry , combinatorial chemistry , chemical synthesis , microarray , group (periodic table) , organic chemistry , biochemistry , gene expression , in vitro , gene
Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o ‐nitrobenzyl derivatives, benzoyl‐ and thiophenyl‐NPPOC, undergo photo‐deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two‐ and twelvefold increase in photo‐deprotection efficiency was proven using photolithograph synthesis of microarrays.