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Designed Enclosure Enables Guest Binding Within the 4200 Å 3 Cavity of a Self‐Assembled Cube
Author(s) -
Ramsay William J.,
Szczypiński Filip T.,
Weissman Haim,
Ronson Tanya K.,
Smulders Maarten M. J.,
Rybtchinski Boris,
Nitschke Jonathan R.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501892
Subject(s) - cube (algebra) , supramolecular chemistry , enclosure , crystallography , self assembly , chemistry , transmission electron microscopy , molecule , nanotechnology , chemical physics , materials science , crystal structure , geometry , computer science , organic chemistry , mathematics , telecommunications
Abstract Metal–organic self‐assembly has proven to be of great use in constructing structures of increasing size and intricacy, but the largest assemblies lack the functions associated with the ability to bind guests. Here we demonstrate the self‐assembly of two simple organic molecules with Cd II and Pt II into a giant heterometallic supramolecular cube which is capable of binding a variety of mono‐ and dianionic guests within an enclosed cavity greater than 4200 Å 3 . Its structure was established by X‐ray crystallography and cryogenic transmission electron microscopy. This cube is the largest discrete abiological assembly that has been observed to bind guests in solution; cavity enclosure and coulombic effects appear to be crucial drivers of host–guest chemistry at this scale. The degree of cavity occupancy, however, appears less important: the largest guest studied, bound the most weakly, occupying only 11 % of the host cavity.