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Exogenous‐Base‐Free Palladacycle‐Catalyzed Highly Enantioselective Arylation of Imines with Arylboroxines
Author(s) -
Schrapel Carmen,
Peters René
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501846
Subject(s) - stereocenter , imine , aldimine , enantioselective synthesis , chemistry , aryl , catalysis , ligand (biochemistry) , ferrocene , combinatorial chemistry , organic chemistry , biochemistry , alkyl , receptor , electrode , electrochemistry
Enantiomerically pure benzylic amines are important for the development of new drugs. A readily accessible planar‐chiral ferrocene‐derived palladacycle is shown to be a highly efficient catalyst for the formation of N‐substituted benzylic stereocenters; this catalyst accelerates the 1,2‐addition of arylboroxines to aromatic and aliphatic imines with exceptional levels of enantioselectivity. Using aldimines an exogenous base was not necessary for the activation of the boroxines, when acetate was used as an anionic ligand. Common problems such as aryl–aryl homocouplings and imine hydrolysis were fully overcome, the latter even in the absence of molecular sieves.