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Highly Enantioselective Transfer Hydrogenation of Ketones with Chiral (NH) 2 P 2 Macrocyclic Iron(II) Complexes
Author(s) -
Bigler Raphael,
Huber Raffael,
Mezzetti Antonio
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501807
Subject(s) - enantioselective synthesis , catalysis , chemistry , yield (engineering) , ligand (biochemistry) , transfer hydrogenation , medicinal chemistry , polar , combinatorial chemistry , stereochemistry , polymer chemistry , organic chemistry , materials science , receptor , ruthenium , biochemistry , physics , astronomy , metallurgy
Bis(isonitrile) iron(II) complexes bearing a C 2 ‐symmetric diamino (NH) 2 P 2 macrocyclic ligand efficiently catalyze the hydrogenation of polar bonds of a broad scope of substrates (ketones, enones, and imines) in high yield (up to 99.5 %), excellent enantioselectivity (up to 99 % ee ), and with low catalyst loading (generally 0.1 mol %). The catalyst can be easily tuned by modifying the substituents of the isonitrile ligand.