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Back Cover: Phosphine‐Catalyzed Remote β‐CH Functionalization of Amines Triggered by Trifluoromethylation of Alkenes: One‐Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles (Angew. Chem. Int. Ed. 13/2015)
Author(s) -
Yu Peng,
Zheng ShengCai,
Yang NingYuan,
Tan Bin,
Liu XinYuan
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501767
Subject(s) - phosphine , trifluoromethylation , chemistry , surface modification , reagent , alkene , catalysis , trifluoromethyl , combinatorial chemistry , tandem , amine gas treating , medicinal chemistry , organic chemistry , materials science , alkyl , composite material
A CF 3 radical could be generated from Togni's reagent in a single‐electron‐transfer process catalyzed by a simple phosphine. In their Communication on page 4041 ff., B. Tan, X.‐Y. Liu, and co‐workers utilize this chemistry to realize the first phosphine‐catalyzed radical tandem route that enables the concomitant functionalization of an alkene and the remote β‐C sp 3H bond of amine derivatives to give bistrifluoromethylated enamides and trisubstituted 5‐(trifluoromethyl)oxazoles, respectively.