Premium
Cyclic Hypervalent Iodine Reagents and Iron Catalysts: The Winning Team for Late‐Stage CH Azidation
Author(s) -
Vita Maria Victoria,
Waser Jerome
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501666
Subject(s) - hypervalent molecule , iodine , reagent , catalysis , stage (stratigraphy) , chemistry , combinatorial chemistry , organic chemistry , biology , paleontology
1+1=3 : By combining the exceptional reactivities of cyclic hypervalent iodine reagents and iron catalysts, Sharma and Hartwig achieved the azidation of CH bonds with unprecedented efficiency and selectivity. The late‐stage introduction of azides into complex bioactive molecules will greatly facilitate the synthesis of analogues and accelerate the discovery of new chemical entities.