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Machine‐Assisted Organic Synthesis
Author(s) -
Ley Steven V.,
Fitzpatrick Daniel E.,
Myers Rebecca M.,
Battilocchio Claudio,
Ingham Richard. J.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501618
Subject(s) - modular design , slurry , organic synthesis , process engineering , computer science , systems engineering , nanotechnology , biochemical engineering , environmental science , materials science , engineering , chemistry , organic chemistry , environmental engineering , catalysis , operating system
In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors. In the rapidly changing, multivariant environment of the research laboratory, equipment needs to be modular to accommodate high and low temperatures and pressures, enzymes, multiphase systems, slurries, gases, and organometallic compounds. Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods. All of these areas create both opportunities and challenges during adoption as enabling technologies.