A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds | Zendy

Poh JianSiang | Zendy; Tran Duc N. | Zendy; Battilocchio Claudio | Zendy; Hawkins Joel M. | Zendy; Ley Steven V. | Zendy

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A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds

Author(s) -

Poh JianSiang,

Tran Duc N.,

Battilocchio Claudio,

Hawkins Joel M.,

Ley Steven V.

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201501538

Subject(s) - diazo , functional group , chemistry , combinatorial chemistry , terminal (telecommunication) , coupling (piping) , transformation (genetics) , allene , continuous flow , flow chemistry , catalysis , organic chemistry , computer science , materials science , engineering , biochemical engineering , telecommunications , biochemistry , metallurgy , gene , polymer

A copper‐catalyzed coupling reaction between flow‐generated unstabilized diazo compounds and terminal alkynes provides di‐ and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

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