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A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds
Author(s) -
Poh JianSiang,
Tran Duc N.,
Battilocchio Claudio,
Hawkins Joel M.,
Ley Steven V.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501538
Subject(s) - diazo , flow (mathematics) , chemistry , medicinal chemistry , physics , mechanics
A copper‐catalyzed coupling reaction between flow‐generated unstabilized diazo compounds and terminal alkynes provides di‐ and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.