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Far‐Red and Near‐IR AIE‐Active Fluorescent Organic Nanoprobes with Enhanced Tumor‐Targeting Efficacy: Shape‐Specific Effects
Author(s) -
Shao Andong,
Xie Yongshu,
Zhu Shaojia,
Guo Zhiqian,
Zhu Shiqin,
Guo Jin,
Shi Ping,
James Tony D.,
Tian He,
Zhu WeiHong
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501478
Subject(s) - aggregation induced emission , fluorescence , nanotechnology , quinoline , rational design , biocompatible material , materials science , in vivo , small molecule , biophysics , chemistry , biomedical engineering , organic chemistry , biochemistry , medicine , physics , microbiology and biotechnology , quantum mechanics , biology
The rational design of high‐performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation‐induced emission (AIE)‐active organic molecules to realize preferable far‐red and NIR fluorescence, well‐controlled morphology (from rod‐like to spherical), and also tumor‐targeted bioimaging. The shape‐tailored organic quinoline–malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell‐tracking applications. Impressively, the spherical shape of QM‐5 nanoaggregates exhibits excellent tumor‐targeted bioimaging performance after intravenously injection into mice, but not the rod‐like aggregates of QM‐2.