Premium
Catalytic Enantioselective Synthesis of N,C α ,C α ‐Trisubstituted α‐Amino Acid Derivatives Using 1 H ‐Imidazol‐4(5 H )‐ones as Key Templates
Author(s) -
Etxabe Julen,
Izquierdo Joseba,
Landa Aitor,
Oiarbide Mikel,
Palomo Claudio
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501275
Subject(s) - enantioselective synthesis , template , stereocenter , chemistry , catalysis , amino acid , combinatorial chemistry , aryl , nucleophile , stereochemistry , alkyl , medicinal chemistry , organic chemistry , nanotechnology , materials science , biochemistry
1 H ‐Imidazol‐4(5 H )‐ones are introduced as novel nucleophilic α‐amino acid equivalents in asymmetric synthesis. These compounds not only allow highly efficient construction of tetrasubstituted stereogenic centers, but unlike hitherto known templates, provide direct access to N‐substituted (alkyl, allyl, aryl) α‐amino acid derivatives.