Rhodium(III)‐Catalyzed [3+2]/[5+2] Annulation of 4‐Aryl 1,2,3‐Triazoles with Internal Alkynes through Dual C(sp 2 )H Functionalization | Zendy

Yang Yuan | Zendy; Zhou MingBo | Zendy; Ouyang XuanHui | Zendy; Pi Rui | Zendy; Song RenJie | Zendy; Li JinHeng | Zendy

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Rhodium(III)‐Catalyzed [3+2]/[5+2] Annulation of 4‐Aryl 1,2,3‐Triazoles with Internal Alkynes through Dual C(sp 2 )H Functionalization

Author(s) -

Yang Yuan,

Zhou MingBo,

Ouyang XuanHui,

Pi Rui,

Song RenJie,

Li JinHeng

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201501260

Subject(s) - annulation , rhodium , azepine , surface modification , aryl , catalysis , chemistry , carbene , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , alkyl

A rhodium(III)‐catalyzed [3+2]/[5+2] annulation of 4‐aryl 1‐tosyl‐1,2,3‐triazoles with internal alkynes is presented. This transformation provides straightforward access to indeno[1,7‐ cd ]azepine architectures through a sequence involving the formation of a rhodium(III) azavinyl carbene, dual C(sp 2 )H functionalization, and [3+2]/[5+2] annulation.

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