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Total Synthesis of Schilancitrilactones B and C
Author(s) -
Wang Liang,
Wang Hengtao,
Li Yihang,
Tang Pingping
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201501169
Subject(s) - total synthesis , intramolecular force , intermolecular force , ring (chemistry) , chemistry , sequence (biology) , stereochemistry , halogenation , organic chemistry , molecule , biochemistry
The first total syntheses of schilancitrilactones B and C have been accomplished in 17 steps (longest linear sequence) from commercially available materials. Key steps include an intramolecular radical cyclization to provide the seven‐membered ring, late‐stage iodination, and an intermolecular radical addition reaction to complete the total synthesis.