Premium
Highly Efficient Ruthenium‐Catalyzed N‐Formylation of Amines with H 2 and CO 2
Author(s) -
Zhang Lei,
Han Zhaobin,
Zhao Xiaoyu,
Wang Zheng,
Ding Kuiling
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500939
Subject(s) - formylation , formamides , ruthenium , catalysis , formamide , chemistry , pincer movement , methanol , ammonia , combinatorial chemistry , dimethylformamide , organic chemistry , selectivity , medicinal chemistry , solvent
A highly efficient catalyst system based on ruthenium‐pincer‐type complexes has been discovered for N‐formylation of various amines with CO 2 and H 2 , thus affording the corresponding formamides with excellent productivity (turnover numbers of up to 1 940 000 in a single batch) and selectivity. Using a simple catalyst recycling protocol, the catalyst was reused for 12 runs in N , N ‐dimethylformamide production without significant loss of activity, thus demonstrating the potential for practical utilization of this cost‐effective process. A one‐pot two‐step procedure for hydrogenation of CO 2 to methanol via the intermediacy of formamide formation has also been developed.