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Bioinspired Therapeutic Dendrimers as Efficient Peptide Drugs Based on Supramolecular Interactions for Tumor Inhibition
Author(s) -
Zhang Xiao,
Zhang Zhijun,
Xu Xianghui,
Li Yunkun,
Li Yachao,
Jian Yeting,
Gu Zhongwei
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500683
Subject(s) - dendrimer , supramolecular chemistry , peptide , indole test , chemistry , tryptophan , combinatorial chemistry , in vitro , amino acid , biophysics , stereochemistry , biochemistry , molecule , organic chemistry , biology
Bioinspired tryptophan‐rich peptide dendrimers (TRPDs) are designed as a new type of dendritic peptide drugs for efficient tumor therapy. The TRPDs feature a precise molecular structure and excellent water solubility and are obtained in a facile process. Based on the unique features of peptide dendrimers, including highly branched structures, abundant terminal groups, and globular‐protein‐like architectures, the therapeutic dendrimers show significant supramolecular interactions with DNA through the tryptophan residues (indole rings and amino groups). Further experimental results indicate that TRPDs are efficient antitumor agents both in vitro and in vivo.