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Responsive Inverse Opal Hydrogels for the Sensing of Macromolecules
Author(s) -
Couturier JeanPhilippe,
Sütterlin Martin,
Laschewsky André,
Hettrich Cornelia,
Wischerhoff Erik
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500674
Subject(s) - analyte , self healing hydrogels , macromolecule , materials science , ethylene glycol , nanotechnology , lower critical solution temperature , biosensor , inverse , polymer , biological system , chemistry , chromatography , polymer chemistry , organic chemistry , copolymer , geometry , mathematics , composite material , biology , biochemistry
Dual responsive inverse opal hydrogels were designed as autonomous sensor systems for (bio)macromolecules, exploiting the analyte‐induced modulation of the opal’s structural color. The systems that are based on oligo(ethylene glycol) macromonomers additionally incorporate comonomers with various recognition units. They combine a coil‐to‐globule collapse transition of the LCST type with sensitivity of the transition temperature toward molecular recognition processes. This enables the specific detection of macromolecular analytes, such as glycopolymers and proteins, by simple optical methods. While the inverse opal structure assists the effective diffusion even of large analytes into the photonic crystal, the stimulus responsiveness gives rise to strong shifts of the optical Bragg peak of more than 100 nm upon analyte binding at a given temperature. The systems’ design provides a versatile platform for the development of easy‐to‐use, fast, and low‐cost sensors for pathogens.