Premium
Controlling the Origins of Inflammation with a Photoactive Lipopeptide Immunopotentiator
Author(s) -
Mancini Rock J.,
Stutts Lalisa,
Moore Troy,
EsserKahn Aaron P.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500416
Subject(s) - inflammation , autocrine signalling , immune system , paracrine signalling , microbiology and biotechnology , immunopotentiator , biology , cell signaling , dendritic cell , immunology , signal transduction , chemistry , cell culture , receptor , biochemistry , genetics
Inflammatory immune responses are mediated by signaling molecules that are both produced by and recognized across highly heterogeneous cell populations. As such, the study of inflammation using traditional immunostimulants is complicated by paracrine and autocrine signaling, which obscures the origin of a propagating response. To address this challenge, we developed a small‐molecule probe that can photosensitize immune cells, thus allowing light‐mediated inflammation. This probe was used to control the origin of inflammation using light. Following this motif, inflammation was initiated from fibroblasts or dendritic cells. The contributions of fibroblasts and dendritic cells in initiating inflammation in heterogeneous co‐culture are reported, thus providing insights into the future development of vaccines and treatment of inflammation.