Premium
Ruthenium‐Catalyzed CC Coupling of Fluorinated Alcohols with Allenes: Dehydrogenation at the Energetic Limit of β‐Hydride Elimination
Author(s) -
Sam Bran,
Luong Tom,
Krische Michael J.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500238
Subject(s) - ruthenium , dehydrogenation , chemistry , catalysis , hydride , coupling (piping) , carbon fibers , medicinal chemistry , organic chemistry , photochemistry , hydrogen , materials science , composite material , metallurgy , composite number
Ruthenium(II) complexes catalyze the CC coupling of 1,1‐disubstituted allenes and fluorinated alcohols to form homoallylic alcohols bearing all‐carbon quaternary centers with good to complete levels of diastereoselectivity. Whereas fluorinated alcohols are relatively abundant and tractable, the corresponding aldehydes are often not commercially available because of their instability.