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Palladium‐Catalyzed Enantioselective CH Arylation for the Synthesis of P‐Stereogenic Compounds
Author(s) -
Lin ZiQi,
Wang WeiZhen,
Yan ShaoBai,
Duan WeiLiang
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500201
Subject(s) - stereocenter , enantioselective synthesis , palladium , catalysis , chemistry , biphenyl , stereochemistry , combinatorial chemistry , organic chemistry
Abstract A palladium‐catalyzed enantioselective CH arylation of N ‐( o ‐bromoaryl)‐diarylphosphinic amides is described for the synthesis of phosphorus compounds bearing a P‐stereogenic center. The method provides good enantioselectivities and high yields. The products were readily transformed into P‐chiral biphenyl monophosphine ligands.