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Microscale Crystals of Cytochrome c and Calixarene on Electrodes: Interprotein Electron Transfer between Defined Sites
Author(s) -
McGovern Róise E.,
Feifel Sven C.,
Lisdat Fred,
Crowley Peter B.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500191
Subject(s) - electron transfer , cyclic voltammetry , electrode , calixarene , chemistry , microscale chemistry , monolayer , cytochrome c , horizontal scan rate , redox , electrochemistry , biosensor , crystallography , analytical chemistry (journal) , photochemistry , inorganic chemistry , molecule , organic chemistry , biochemistry , mitochondrion , mathematics education , mathematics
The assembly of redox proteins on electrodes is an important step in biosensor development. Recently, p ‐sulfonato‐calix[4]arene was shown to act as “molecular glue” for the assembly and crystallization of cytochrome c (cyt c ). Electrochemical data are presented for microscale cyt c –calixarene crystals grown on self‐assembled monolayers (SAM)‐modified Au electrodes. The crystals were characterized by cyclic voltammetry and exceptionally high concentrations of electroactive cyt c were obtained. The peak currents were found to increase linearly with the square root of the scan rate, thus allowing an evaluation of the rate constant for electron self‐exchange. This study revealed high electroactivity accompanied by fast interprotein electron transfer in crystals, which may have implications for the construction of novel bioelectronic devices.