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Inside Back Cover: Highly Diastereoselective and Enantioselective Olefin Cyclopropanation Using Engineered Myoglobin‐Based Catalysts (Angew. Chem. Int. Ed. 6/2015)
Author(s) -
Bordeaux Melanie,
Tyagi Vikas,
Fasan Rudi
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500136
Subject(s) - cyclopropanation , enantioselective synthesis , myoglobin , catalysis , olefin fiber , chemistry , rational design , combinatorial chemistry , aryl , organic chemistry , materials science , nanotechnology , alkyl
Engineered variants of sperm whale myoglobin enable the selective cyclopropanation of aryl‐substituted olefins with α‐diazo esters in water. In their Communication on page 1744 ff., R. Fasan and co‐workers report the rational design of myoglobin‐based catalysts capable of mediating this transformation with an unprecedented combination of high catalytic efficiency and excellent diastereo‐ and enantioselectivity.