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Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery
Author(s) -
Zhang Lu,
Feng Qiang,
Wang Jiuling,
Sun Jiashu,
Shi Xinghua,
Jiang Xingyu
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500096
Subject(s) - reagent , calcein , dissipative particle dynamics , microfluidics , plga , materials science , nanotechnology , doxorubicin , chemistry , combinatorial chemistry , chemical engineering , nanoparticle , membrane , polymer , organic chemistry , biochemistry , medicine , surgery , chemotherapy , engineering , composite material
Abstract We present a hollow‐structured rigid nanovesicle (RNV) fabricated by a multi‐stage microfluidic chip in one step, to effectively entrap various hydrophilic reagents inside, without complicated synthesis, extensive use of emulsifiers and stabilizers, and laborious purification procedures. The RNV contains a hollow water core, a rigid poly (lactic‐co‐glycolic acid) (PLGA) shell, and an outermost lipid layer. The formation mechanism of the RNV is investigated by dissipative particle dynamics (DPD) simulations. The entrapment efficiency of hydrophilic reagents such as calcein, rhodamine B and siRNA inside the hollow water core of RNV is ≈90 %. In comparison with the combination of free Dox and siRNA, RNV that co‐encapsulate siRNA and doxorubicin (Dox) reveals a significantly enhanced anti‐tumor effect for a multi‐drug resistant tumor model.