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A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential CH Functionalization
Author(s) -
Pitts Andrew K.,
O'Hara Fionn,
Snell Robert H.,
Gaunt Matthew J.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201500067
Subject(s) - surface modification , natural product , total synthesis , combinatorial chemistry , core (optical fiber) , chemistry , computer science , stereochemistry , telecommunications
A sequential CH functionalization strategy for the synthesis of the marine alkaloid dictyodendrin B is reported. Our synthesis begins from commercially available 4‐bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram‐scale strategy towards the natural product.