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Frontispiece: Intramolecular Metalloamination of N , N ‐Dimethylhydrazinoalkenes: A Versatile Method to Access Functionalized Piperidines and Pyrrolidines
Author(s) -
Sunsdahl Bryce,
Smith Adrian R.,
Livinghouse Tom
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201485261
Subject(s) - intramolecular force , electrophile , cascade , combinatorial chemistry , chemistry , chelation , stereochemistry , medicinal chemistry , organic chemistry , catalysis , chromatography
Heterocycle Synthesis In their Communication on page 14352 ff., T. Livinghouse et al. describe the direct metalloamination/cyclization of hydrazinoalkenes by Et 2 Zn. Electrophilic capture of the chelated organozinc intermediates drives the subsequent cascade.