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Molecularly Imprinted Polymer Nanomaterials and Nanocomposites: Atom‐Transfer Radical Polymerization with Acidic Monomers
Author(s) -
AdaliKaya Zeynep,
Tse Sum Bui Bernadette,
FalcimaigneCordin Aude,
Haupt Karsten
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201412494
Subject(s) - molecularly imprinted polymer , atom transfer radical polymerization , monomer , polymer , polymerization , reversible addition−fragmentation chain transfer polymerization , materials science , nanomaterials , surface modification , nanoparticle , combinatorial chemistry , polymer chemistry , radical polymerization , chain transfer , nanotechnology , chemical engineering , chemistry , organic chemistry , catalysis , selectivity , engineering
Molecularly imprinted polymers (MIPs) are artificial receptors which can be tailored to bind target molecules specifically. A new method, using photoinitiated atom‐transfer radical polymerization (ATRP) for their synthesis as monoliths, thin films and nanoparticles is described. The synthesis takes place at room temperature and is compatible with acidic monomers, two major limitations for the use of ATRP with MIPs. The method has been validated with MIPs specific for the drugs testosterone and S ‐propranolol. This study considerably widens the range of functional monomers and thus molecular templates which can be used when MIPs are synthesized by ATRP, as well as the range of physical forms of these antibody mimics, in particular films and lithographic patterns, and their post‐functionalization from living chain‐ends.